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KMID : 0365819650050010143
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Journal of Pusan Medical College
1965 Volume.5 No. 1 p.143 ~ p.141
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Studies on the pathological, histochemical findings and radioisotopy scanning of the liver in rabbits experimentally infected with Clonorchis sinensis
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Abstract
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The author made 3 groups of rabbits, A, B and C. Each group was infested with metacercarias of Clonorchis sinensis orally. A group was infested with 500 metacercarias, B group with 1000 metacercarias, C group with 3000 metacercarias orally respectively.
A, B and C group were observed for 25, 50 and 75 days after infestation respectively and after then the rabbits were killed after taking liver scanning figures with radioisotope colloidal gold. The histopathological findings also were obtained from this study.
The results summarize as follows.
(1) Ovum-positive in stool test was from 17 days to 28 days (mean 23 days) after infestation of metacercarias.
(2) The number of the worms in each group was 230 (46.0%) in A group, 410 (41.0%) in B group and 1240 (41. 3 %) in C group.
(3) According to the pathological findings, 25 days after infestation, proliferation of bile duct and interstitial tissue was present but no formation of pseudolobules or liver cirrhosis were found, 50 days after infestation, marked cirrhotic changes present in comparison with the number of the worms.
(4) The alkaline phosphatase activity of the liver cells decreased in accordance with the number of the worms and duration of infestation but still remained in the regenerative liver cells.
(5) The liver scintigram showed defective areas, and mottled appearance due to the decreased radioisotope uptake as the cirrhotic changes of liver progressed.
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